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Inspectors are permitted to visit farms and choose plants for testing. Plants that have more than .3% THC but less than 1% will be retested and possibly destroyed. THC levels above 1% result in immediate destruction and investigation by law enforcement.
Its creator, Mr. Green of the House of David Collective, was prompted to have its CBD levels tested when some of his friends reported that while they loved the smell, taste, and frosty appearance of the strain, it didn’t get them very high. Harlequin strain tested at a surprising 7% CBD and 7% THC—though it is worth noting that the specific phenotype reviewed for this article tested at an astounding 11% CBD, and a different phenotype of the same plant tested at less than 1% CBD. Harlequin is indeed a rare find.
The trial was conducted between March 2017 and September 2017 in an outpatient derma-esthetic clinic. All the subjects completed the study. In comparison with baseline value, skin dryness was significantly ( p =0.001; Wilcoxon test) reduced by 59.5% (from 3.6±0.7 to 1.5±0.4) on the side treated with Mel creams. Skin dryness score was significantly lower in the active-treated side in comparison with the non-treated side ( p =0.01; Mann–Whitney U test; 1.5±0.4 vs 3.5±0.6; Figure 1A). Skin tonicity (resistance to traction, resistance to pinching and recovery after pinching) significantly improved by 33% in comparison with the baseline value on the side treated with Mel creams only (from 3.0±0.5 to 2.1±0.4; Figure 1B and C). Crow’s feet photographic severity score was reduced significantly ( p =0.05) by -15% with the creams in comparison with both baseline value (2.3±0.2 vs. 2.7±0.3) and value of the non-treated side after 3 months. Surface microrelief photographic score was significantly reduced by -26.5% at the end of treatment in comparison with both baseline value (2.4±0.5 vs. 3.4±0.6; p =0.001; Wilcoxon test) and value of the control side at month 3 (2.4±0.5 vs. 3.3±0.6; p =0.001; Mann–Whitney U test). Significant improvements were also observed starting from month 1 on the sides treated with the active product (ANOVA test; data not shown). For all the skin parameters evaluated, nonstatistical significant modifications have been observed in the control side comparing baseline and 3-month values. Figure 2 shows the evolution of the Spiderming graph with a significant reduction in the total area after active treatment in comparison with baseline and non-treated sides. Skin profilometry evaluation showed a -13% reduction in roughness profile, –13% reduction in wrinkles’ maximum depth and –7.2% reduction in total wrinkles’ height in comparison with baseline and control sides. However, these reductions, although clinically relevant, did not reach a statistical significant difference. Figure 3 shows two subjects’ pictures performed with Vectra at baseline and after 3 months of treatment. Both products (day and night creams) were well tolerated. No side effects were reported. Compliance to the treatment was >90% in all the enrolled subjects.
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